General Information

  • ID:  hor004834
  • Uniprot ID:  P68126
  • Protein name:  Cholecystokinin
  • Gene name:  CCK
  • Organism:  Notamacropus eugenii (Tammar wallaby) (Macropus eugenii)
  • Family:  Gastrin/cholecystokinin family
  • Source:  Animal
  • Expression:  In larvae, expressed in the ring gland but not in midgut, CNS, thoracic perisympathetic organs (tPSO) and abdominal perisympathetic organs (aPSO). In adults, expressed in corpora cardiaca and corpora allata but not in brain and thoracic-abdominal ganglion
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Notamacropus (genus), Macropodidae (family), Diprotodontia (order), Metatheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  DYMGWMDF
  • Length:  8(1-8)
  • Propeptide:  DYMGWMDF
  • Signal peptide:  NA
  • Modification:  T2 Sulfotyrosine;T8 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates
  • Mechanism:  NA
  • Cross BBB:  YES
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: 18 minute; /1080 seconds ( PubMed ID: 6291099 )

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004834_AF2.pdbhor004834_ESM.pdb

Physical Information

Mass: 118924 Formula: C49H61N9O14S2
Absent amino acids: ACEHIKLNPQRSTV Common amino acids: DM
pI: 3.49 Basic residues: 0
Polar residues: 2 Hydrophobic residues: 2
Hydrophobicity: -37.5 Boman Index: -663
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 0
Instability Index: 9927.5 Extinction Coefficient cystines: 6990
Absorbance 280nm: 998.57

Literature

  • PubMed ID:  3375140##6291099
  • Title:  Cholecystokinin octapeptide purified from brains of Australian marsupials.